{"product_id":"calocurb®-clinical-maintenance-pack","title":"Calocurb CLINICAL Maintenance Pack","description":"\u003cp class=\"mb-4\"\u003e\u003cstrong\u003eCalocurb\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cstrong\u003e CLINICAL\u003c\/strong\u003e is a practitioner-exclusive supplement that supports appetite control by working with the body’s natural hormonal signals. It features Amarasate\u003c\/span\u003e\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e, a clinically studied extract of New Zealand bitter hops, delivered in a delayed-release capsule designed to reach the small intestine where it activates bitter taste receptors. This triggers the release of key satiety hormones including GLP-1, CCK and PYY, which work together to significantly reduce hunger, cravings, and caloric intake. Fast-acting and plant-based, Calocurb\u003c\/span\u003e\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e CLINICAL offers a targeted, science-driven approach to supporting healthy weight management.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces Appetite and Food Cravings\u003c\/li\u003e\n\u003cli\u003eSupports Long-Term Weight Management\u003c\/li\u003e\n\u003cli\u003eStimulates Natural GLP-1, CCK and PYY Release\u003c\/li\u003e\n\u003cli\u003eComplements Lifestyle and Pharmaceutical Weight Loss Strategies\u003c\/li\u003e\n\u003cli\u003eEnhances Adherence to Intermittent Fasting and Time-Restricted Eating\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSuccessful weight management is now a global health concern as more than 43% of adults are categorized as overweight or obese. Long term weight management requires lifestyle modification but often includes higher-force interventions such as pharmaceutical or surgical care. Pharmaceutical interventions are usually designed to reduce food intake by manipulating appetite; however, these interventions have long-term feasibility or safety concerns. Naturally derived compounds, with favorable safety profiles and the ability to powerfully suppress appetite and cravings, represent an appealing option for ongoing weight management.\u003c\/p\u003e\n\u003cp\u003eAppetite regulation is orchestrated by a complex network of physical and chemical signals, with enteroendocrine hormones serving as some of the most powerful drivers of hunger and satiety. Under normal physiology, orexigenic hormones such as ghrelin rise during fasting and between meals, while anorexigenic hormones including GLP-1, CCK and PYY are released after eating. Specialized enteroendocrine cells in the gastrointestinal tract release these hormones in a dose- and time-dependent manner in response to nutrient intake.\u003c\/p\u003e\n\u003cp\u003eIn 2010, the New Zealand government funded a large grant to investigate the appetite suppressive effects of bitter plant compounds as a potential treatment option for weight management. After investigating over 1,000 different plant compounds in vitro, the researchers concluded that a native New Zealand hops extract produced the strongest TAS2R stimulation and consequential enhanced release of anorexigenic (GLP-1, CCK and PYY) hormonal response, indicating the strongest appetite suppressant effect. The researchers named the extract Amarasate\u003csup\u003e®\u003c\/sup\u003e, derived from Latin, meaning “bitter satiation.”\u003c\/p\u003e\n\u003cp\u003ePatients should use the Calocurb\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eCLINICAL Maintenance pack following the\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.orthomolecularproducts.com\/product\/calocurb-clinical-starter-pack\"\u003eStarter Pack\u003c\/a\u003e. As-needed administration is recommended only for those experienced with Calocurb® CLINICAL and knowledgeable of their individual response.\u003c\/p\u003e\n\u003cp\u003eIn 2019, the first clinical study on Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003ewas conducted in a randomized, double-blind trial investigating its appetite suppressive effects during a 24-hour, water-only fast. Participants given Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eor placebo at hours 16 and 20 were evaluated for hunger and satiety with a standard visual analog scale (VAS) every 30 minutes after capsule administration. Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eparticipants reported an 80% reduction in hunger elevation scores compared to the placebo group. In a comparable water-fast study conducted in women, Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003esupplementation led to a 100% suppression of hunger elevation and a 120% reduction in food cravings relative to placebo.\u003c\/p\u003e\n\u003cp\u003eA more expansive study of adult men sought to correlate the subjective reduction in hunger from the first study with anorexigenic biomarkers, specifically GLP-1, CCK and PYY. The study also sought to investigate which was more efficacious, intragastric or intraduodenal delivery of Amarasate\u003csup\u003e®\u003c\/sup\u003e. In the randomized, double-blind study, the subjects were given either placebo, intraduodenal Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003e(delayed-release capsule), or intragastric Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003e(immediate-release capsule) one hour before an ad libitum meal and subsequent snack. Both Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003edelivery methods had significant elevations in GLP-1, CCK and PYY; however, the intragastric capsule also had significantly more adverse events than the intraduodenal capsule likely due to the high amount of TAS2R bitter receptors in the stomach. Intraduodenal delivery of Amarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eresulted in 600% elevation from baseline of GLP-1 and CCK, and 50% elevation of PYY.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCLINICAL CONSIDERATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAmarasate\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eis a potent and effective appetite modulator, offering a targeted approach to supporting satiety and caloric control. It can be used independently or integrated into a comprehensive strategy for weight loss or maintenance. Calocurb\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eCLINICAL may be co-administered with weight-loss medications to help manage breakthrough hunger or used during medication tapering to support appetite control. Alternatively, Calocurb\u003csup\u003e®\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eCLINICAL can also be used as needed to support adherence to time-restricted eating or to help manage appetite and craving increases that may occur premenstrually.\u003c\/p\u003e","brand":"Ortho Molecular","offers":[{"title":"Default Title","offer_id":51265030258970,"sku":"OTM-0239060","price":66.35,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0667\/2334\/8762\/files\/CalocurbCLINICALMaintenancePack.png?v=1770148566","url":"https:\/\/wholesale.inwellbio.com\/products\/calocurb%c2%ae-clinical-maintenance-pack","provider":"InwellBio","version":"1.0","type":"link"}